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Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery

Penicillin and related beta-lactams comprise one of our oldest and most widely used antibiotic therapies. These drugs have long been known to target enzymes called penicillin-binding proteins (PBPs) that build the bacterial cell wall. Investigating the downstream consequences of target inhibition an...

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Bibliografiska uppgifter
I publikationen:Cell
Huvudupphovsmän: Cho, Hongbaek, Uehara, Tsuyoshi, Bernhardt, Thomas G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258230/
https://ncbi.nlm.nih.gov/pubmed/25480295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.017
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