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Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery

Penicillin and related beta-lactams comprise one of our oldest and most widely used antibiotic therapies. These drugs have long been known to target enzymes called penicillin-binding proteins (PBPs) that build the bacterial cell wall. Investigating the downstream consequences of target inhibition an...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Cho, Hongbaek, Uehara, Tsuyoshi, Bernhardt, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258230/
https://ncbi.nlm.nih.gov/pubmed/25480295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.017
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