Serine catabolism regulates mitochondrial redox control during hypoxia

The de novo synthesis of the non-essential amino acid serine is often upregulated in cancer. In this study we demonstrate that the serine catabolic enzyme, mitochondrial serine hydroxymethyltransferase (SHMT2) is induced when Myc-transformed cells are subjected to hypoxia. In mitochondria, SHMT2 can...

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Vydáno v:Cancer Discov
Hlavní autoři: Ye, Jiangbin, Fan, Jing, Venneti, Sriram, Wan, Ying-Wooi, Pawel, Bruce R., Zhang, Ji, Finley, Lydia W.S., Lu, Chao, Lindsten, Tullia, Cross, Justin, Qing, Guoliang, Liu, Zhandong, Simon, M. Celeste, Rabinowitz, Joshua D., Thompson, Craig B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258153/
https://ncbi.nlm.nih.gov/pubmed/25186948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0250
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