Serine catabolism feeds NADH when respiration is impaired

NADH provides electrons for aerobic ATP production. In cells deprived of oxygen or with impaired electron transport chain activity, NADH accumulation can be toxic. To minimize such toxicity, elevated NADH inhibits the classical NADH producing pathways: glucose, glutamine, and fat oxidation. Here, th...

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Publicado no:Cell Metab
Main Authors: Yang, Lifeng, Canaveras, Juan Carlos Garcia, Chen, Zihong, Wang, Lin, Liang, Lingfan, Jang, Cholsoon, Mayr, Johannes A., Zhang, Zhaoyue, Ghergurovich, Jonathan M., Zhan, Le, Joshi, Shilpy, Hu, Zhixian, McReynolds, Melanie R., Su, Xiaoyang, White, Eileen, Morscher, Raphael J., Rabinowitz, Joshua D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397714/
https://ncbi.nlm.nih.gov/pubmed/32187526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.02.017
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