Respiration defects limit serine synthesis required for lung cancer growth and survival
Abstract Mitochondrial function supports energy and anabolic metabolism. Pathogenic mitochondrial DNA (mtDNA) mutations impair these processes, causing mitochondrial diseases. Their role in human cancers is less clear; while some cancers harbor high mtDNA mutation burden, others do not. Here we show...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Nature Portfolio
2025-08-01
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| Schriftenreihe: | Nature Communications |
| Online-Zugang: | https://doi.org/10.1038/s41467-025-62911-7 |
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