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Respiration defects limit serine synthesis required for lung cancer growth and survival

Abstract Mitochondrial function supports energy and anabolic metabolism. Pathogenic mitochondrial DNA (mtDNA) mutations impair these processes, causing mitochondrial diseases. Their role in human cancers is less clear; while some cancers harbor high mtDNA mutation burden, others do not. Here we show...

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Principais autores: Eduardo Cararo Lopes, Fuqian Shi, Akshada Sawant, Maria Ibrahim, Maria Gomez-Jenkins, Zhixian Hu, Pranav Manchiraju, Vrushank Bhatt, Wenping Wang, Christian S. Hinrichs, Douglas C. Wallace, Xiaoyang Su, Joshua D. Rabinowitz, Chang S. Chan, Jessie Yanxiang Guo, Shridar Ganesan, Edmund C. Lattime, Eileen White
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-08-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-025-62911-7
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