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The PHGDH enigma: do cancer cells only need serine or also a redox modulator?

Upregulation of serine biosynthesis pathway activity is an increasingly apparent feature of many cancers. Most notably, the first rate-limiting enzyme of the pathway, phosphoglycerate dehydrogenase (PHGDH), is genomically amplified in some melanomas and breast cancers and can be transcriptionally re...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Lett
Prif Awduron: Li, Albert M., Ye, Jiangbin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092752/
https://ncbi.nlm.nih.gov/pubmed/32032680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.01.036
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