Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

Cancer genome characterization has revealed driver mutations in genes that govern ubiquitylation; however, the mechanisms by which these alterations promote tumorigenesis remain incompletely characterized. Here, we analyzed changes in the ubiquitin landscape induced by prostate cancer-associated mut...

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Publicado no:Science
Main Authors: Theurillat, Jean-Philippe P., Udeshi, Namrata D., Errington, Wesley J., Svinkina, Tanya, Baca, Sylvan C., Pop, Marius, Wild, Peter J., Blattner, Mirjam, Groner, Anna C., Rubin, Mark A., Moch, Holger, Prive, Gilbert G., Carr, Steven A., Garraway, Levi A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257137/
https://ncbi.nlm.nih.gov/pubmed/25278611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1250255
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