IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens

IRAK-4 and MyD88 deficiencies impair interleukin 1 receptor and Toll-like receptor (TLR) signaling and lead to heightened susceptibility to invasive bacterial infections. Individuals with these primary immunodeficiencies have fewer immunoglobulin M (IgM)(+)IgD(+)CD27(+) B cells, a population that re...

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Veröffentlicht in:Blood
Hauptverfasser: Maglione, Paul J., Simchoni, Noa, Black, Samuel, Radigan, Lin, Overbey, Jessica R., Bagiella, Emilia, Bussel, James B., Bossuyt, Xavier, Casanova, Jean-Laurent, Meyts, Isabelle, Cerutti, Andrea, Picard, Capucine, Cunningham-Rundles, Charlotte
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2014
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256908/
https://ncbi.nlm.nih.gov/pubmed/25320238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-587824
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