IgM(+)IgD(+)CD27(+) B cells are markedly reduced in IRAK-4–, MyD88-, and TIRAP- but not UNC-93B–deficient patients

We studied the distribution of peripheral B-cell subsets in patients deficient for key factors of the TLR-signaling pathways (MyD88, TIRAP/MAL, IL-1 receptor–associated kinase 4 [IRAK-4], TLR3, UNC-93B, TRIF). All TLRs, except TLR3, which signals through the TRIF adaptor, require MyD88 and IRAK-4 to...

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主要な著者: Weller, Sandra, Bonnet, Mélanie, Delagreverie, Héloïse, Israel, Laura, Chrabieh, Maya, Maródi, László, Rodriguez-Gallego, Carlos, Garty, Ben-Zion, Roifman, Chaim, Issekutz, Andrew C., Zitnik, Simona Eva, Hoarau, Cyrille, Camcioglu, Yildiz, Vasconcelos, Júlia, Rodrigo, Carlos, Arkwright, Peter D., Cerutti, Andrea, Meffre, Eric, Zhang, Shen-Ying, Alcais, Alexandre, Puel, Anne, Casanova, Jean-Laurent, Picard, Capucine, Weill, Jean-Claude, Reynaud, Claude-Agnès
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2012
主題:
Immunobiology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525023/
https://ncbi.nlm.nih.gov/pubmed/23002119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-440776
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