Multiple intermediates on the energy landscape of a 15-HEAT-repeat protein

Repeat proteins are a special class of modular, non-globular proteins composed of small structural motifs arrayed to form elongated architectures and stabilised solely by short-range contacts. We find a remarkable complexity in the unfolding of the large HEAT repeat protein PR65/A. In contrast to wh...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Tsytlonok, Maksym, Craig, Patricio O., Sivertsson, Elin, Serquera, David, Perrett, Sarah, Best, Robert B., Wolynes, Peter G., Itzhaki, Laura S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256716/
https://ncbi.nlm.nih.gov/pubmed/24120762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.08.028
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