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Discrete Kinetic Models from Funneled Energy Landscape Simulations

A general method for facilitating the interpretation of computer simulations of protein folding with minimally frustrated energy landscapes is detailed and applied to a designed ankyrin repeat protein (4ANK). In the method, groups of residues are assigned to foldons and these foldons are used to map...

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Detalhes bibliográficos
Main Authors: Schafer, Nicholas P., Hoffman, Ryan M. B., Burger, Anat, Craig, Patricio O., Komives, Elizabeth A., Wolynes, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520928/
https://ncbi.nlm.nih.gov/pubmed/23251375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050635
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