Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. We show that FTY720 enters the nucleus, where it is phosphorylated by sphingosine kinase 2 (SphK2)...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Neurosci
Autori principali: Hait, Nitai C, Wise, Laura E, Allegood, Jeremy C, O’Brien, Megan, Avni, Dorit, Reeves, Thomas M, Knapp, Pamela E, Lu, Junyan, Luo, Cheng, Miles, Michael F, Milstien, Sheldon, Lichtman, Aron H, Spiegel, Sarah
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256678/
https://ncbi.nlm.nih.gov/pubmed/24859201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3728
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi