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Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory
FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. We show that FTY720 enters the nucleus, where it is phosphorylated by sphingosine kinase 2 (SphK2)...
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| Pubblicato in: | Nat Neurosci |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4256678/ https://ncbi.nlm.nih.gov/pubmed/24859201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3728 |
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