Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. We show that FTY720 enters the nucleus, where it is phosphorylated by sphingosine kinase 2 (SphK2)...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Neurosci
Egile Nagusiak: Hait, Nitai C, Wise, Laura E, Allegood, Jeremy C, O’Brien, Megan, Avni, Dorit, Reeves, Thomas M, Knapp, Pamela E, Lu, Junyan, Luo, Cheng, Miles, Michael F, Milstien, Sheldon, Lichtman, Aron H, Spiegel, Sarah
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256678/
https://ncbi.nlm.nih.gov/pubmed/24859201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3728
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