Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. We show that FTY720 enters the nucleus, where it is phosphorylated by sphingosine kinase 2 (SphK2)...

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Bibliographic Details
Published in:Nat Neurosci
Main Authors: Hait, Nitai C, Wise, Laura E, Allegood, Jeremy C, O’Brien, Megan, Avni, Dorit, Reeves, Thomas M, Knapp, Pamela E, Lu, Junyan, Luo, Cheng, Miles, Michael F, Milstien, Sheldon, Lichtman, Aron H, Spiegel, Sarah
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256678/
https://ncbi.nlm.nih.gov/pubmed/24859201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3728
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