Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. We show that FTY720 enters the nucleus, where it is phosphorylated by sphingosine kinase 2 (SphK2)...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Hait, Nitai C, Wise, Laura E, Allegood, Jeremy C, O’Brien, Megan, Avni, Dorit, Reeves, Thomas M, Knapp, Pamela E, Lu, Junyan, Luo, Cheng, Miles, Michael F, Milstien, Sheldon, Lichtman, Aron H, Spiegel, Sarah
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256678/
https://ncbi.nlm.nih.gov/pubmed/24859201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3728
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