Crucial Role of C-Jun Phosphorylation at Ser63/73 Mediated by PHLPP Protein Degradation in the Cheliensisin A (Chel A) Inhibition of Cell Transformation

Cheliensisin A (Chel A), as a novel styryl-lactone isolated from Goniothalamus cheliensis Hu, has been demonstrated to have an inhibition of EGF-induced Cl41 cell transformation via stabilizing p53 protein in a Chk1-dependent manner, suggesting its chemopreventive activity in our previous studies. H...

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Détails bibliographiques
Publié dans:Cancer Prev Res (Phila)
Auteurs principaux: Zhu, Junlan, Zhang, Jingjie, Huang, Haishan, Li, Jingxia, Yu, Yonghui, Jin, Honglei, Li, Yang, Deng, Xu, Gao, Jimin, Zhao, Qinshi, Huang, Chuanshu
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256147/
https://ncbi.nlm.nih.gov/pubmed/25281487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0233
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