Cheliensisin A Inhibits EGF-induced Cell Transformation with Stabilization of p53 Protein via a Hydrogen Peroxide/Chk1-dependent Axis

Cheliensisin A (Chel A), a novel styryl-lactone isolated from Goniothalamus cheliensis Hu, has been shown to induce of apoptosis in human promyelocytic leukemia HL-60 cells with Bcl-2 downregulation. Yet the potential chemopreventive effect of Chel A has not been explored. Here we demonstrated that...

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Détails bibliographiques
Auteurs principaux: Zhang, Jingjie, Gao, Guangxun, Chen, Liang, Deng, Xu, Li, Jingxia, Yu, Yonghui, Zhang, Dongyun, Li, Fei, Zhang, Min, Zhao, Qinshi, Huang, Chuanshu
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769189/
https://ncbi.nlm.nih.gov/pubmed/23852422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-13-0097
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