Epithelial sodium channel abundance is decreased by an unfolded protein response induced by hyperosmolality

Large shifts of osmolality occur in the kidney medulla as part of the urine concentrating mechanism. Hyperosmotic stress profoundly challenges cellular homeostasis and induces endoplasmic reticulum (ER) stress. Here, we examined the unfolded protein response (UPR) in hyperosmotically‐challenged prin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Physiol Rep
Auteurs principaux: Crambert, Gilles, Ernandez, Thomas, Lamouroux, Christine, Roth, Isabelle, Dizin, Eva, Martin, Pierre‐Yves, Féraille, Eric, Hasler, Udo
Format: Artigo
Langue:Inglês
Publié: Wiley Periodicals, Inc. 2014
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255800/
https://ncbi.nlm.nih.gov/pubmed/25413317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12169
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