Epithelial sodium channel abundance is decreased by an unfolded protein response induced by hyperosmolality

Large shifts of osmolality occur in the kidney medulla as part of the urine concentrating mechanism. Hyperosmotic stress profoundly challenges cellular homeostasis and induces endoplasmic reticulum (ER) stress. Here, we examined the unfolded protein response (UPR) in hyperosmotically‐challenged prin...

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Detalles Bibliográficos
Publicado en:Physiol Rep
Main Authors: Crambert, Gilles, Ernandez, Thomas, Lamouroux, Christine, Roth, Isabelle, Dizin, Eva, Martin, Pierre‐Yves, Féraille, Eric, Hasler, Udo
Formato: Artigo
Idioma:Inglês
Publicado: Wiley Periodicals, Inc. 2014
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255800/
https://ncbi.nlm.nih.gov/pubmed/25413317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12169
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