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Fragment-Based Screening of the Bromodomain of ATAD2
[Image: see text] Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, an...
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| Udgivet i: | J Med Chem |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2014
|
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4255743/ https://ncbi.nlm.nih.gov/pubmed/25314628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501035j |
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