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Distinct Subcellular Trafficking Resulting from Monomeric vs Multimeric Targeting to Endothelial ICAM-1: Implications for Drug Delivery

[Image: see text] Ligand-targeted, receptor-mediated endocytosis is commonly exploited for intracellular drug delivery. However, cells-surface receptors may follow distinct endocytic fates when bound by monomeric vs multimeric ligands. Our purpose was to study this paradigm using ICAM-1, an endothel...

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Bibliografiska uppgifter
I publikationen:Mol Pharm
Huvudupphovsmän: Ghaffarian, Rasa, Muro, Silvia
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2014
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255724/
https://ncbi.nlm.nih.gov/pubmed/25301142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500409y
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