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Distinct Subcellular Trafficking Resulting from Monomeric vs Multimeric Targeting to Endothelial ICAM-1: Implications for Drug Delivery

[Image: see text] Ligand-targeted, receptor-mediated endocytosis is commonly exploited for intracellular drug delivery. However, cells-surface receptors may follow distinct endocytic fates when bound by monomeric vs multimeric ligands. Our purpose was to study this paradigm using ICAM-1, an endothel...

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書誌詳細
出版年:Mol Pharm
主要な著者: Ghaffarian, Rasa, Muro, Silvia
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2014
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255724/
https://ncbi.nlm.nih.gov/pubmed/25301142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500409y
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