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Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish

The melanocortin-4 receptor (MC4R) is essential for control of energy homeostasis in vertebrates. MC4R interacts with melanocortin receptor accessory protein 2 (MRAP2) in vitro, but its functions in vivo are unknown. We found that MRAP2a, a larval form, stimulates growth of zebrafish by specifically...

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Publicat a:Science
Autors principals: Sebag, Julien A., Zhang, Chao, Hinkle, Patricia M., Bradshaw, Amanda M., Cone, Roger D.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255277/
https://ncbi.nlm.nih.gov/pubmed/23869017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1232995
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