Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

MicroRNAs are small regulatory RNAs that post-transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA processing, is frequently observed in cancer and is associated with poor clinical outcome in various malignancies. Yet the underlying mechanisms are n...

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Pubblicato in:Nat Commun
Autori principali: van den Beucken, Twan, Koch, Elizabeth, Chu, Kenneth, Rupaimoole, Rajesha, Prickaerts, Peggy, Adriaens, Michiel, Voncken, Jan Willem, Harris, Adrian L., Buffa, Francesca M., Haider, Syed, Starmans, Maud H.W., Yao, Cindy Q., Ivan, Mircea, Ivan, Cristina, Pecot, Chad V., Boutros, Paul C., Sood, Anil K., Koritzinsky, Marianne, Wouters, Bradly G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255228/
https://ncbi.nlm.nih.gov/pubmed/25351418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6203
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