Arg287Gln VARIANT OF EPHX2 AND EPOXYEICOSATRIENOIC ACIDS ARE ASSOCIATED WITH INSULIN SENSITIVITY IN HUMANS

Epoxyeicosatrienoic acids (EETs) protect against the development of insulin resistance in rodents. EETs are hydrolyzed to less biologically active diols by soluble epoxide hydrolase (encoded for by EPHX2). Functional variants of EPHX2 encode for enzymes with increased (Lys55Arg) or decreased (Arg287...

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Udgivet i:Prostaglandins Other Lipid Mediat
Main Authors: Ramirez, Claudia E., Shuey, Megan M., Milne, Ginger L., Gilbert, Kimberly, Hui, Nian, Yu, Chang, Luther, James M., Brown, Nancy J.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253976/
https://ncbi.nlm.nih.gov/pubmed/25173047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2014.08.001
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