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1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription
BACKGROUND AND PURPOSE: HIV-1 transcription is activated by the Tat protein which recruits the cyclin-dependent kinase CDK9/cyclin T1 to TAR RNA. Tat binds to protein phosphatase-1 (PP1) through the Q(35)VCF(38) sequence and translocates PP1 to the nucleus. PP1 dephosphorylates CDK9 and activates HI...
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| Pubblicato in: | Br J Pharmacol |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BlackWell Publishing Ltd
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253456/ https://ncbi.nlm.nih.gov/pubmed/25073485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12863 |
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