1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription

BACKGROUND AND PURPOSE: HIV-1 transcription is activated by the Tat protein which recruits the cyclin-dependent kinase CDK9/cyclin T1 to TAR RNA. Tat binds to protein phosphatase-1 (PP1) through the Q(35)VCF(38) sequence and translocates PP1 to the nucleus. PP1 dephosphorylates CDK9 and activates HI...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Ammosova, Tatyana, Platonov, Maxim, Ivanov, Andrei, Kont, Yasemin Saygideğer, Kumari, Namita, Kehn-Hall, Kylene, Jerebtsova, Marina, Kulkarni, Amol A, Üren, Aykut, Kovalskyy, Dmytro, Nekhai, Sergei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BlackWell Publishing Ltd 2014
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253456/
https://ncbi.nlm.nih.gov/pubmed/25073485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12863
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