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Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis

Phosphonium and uronium salt-based reagents enable efficient and effective coupling reactions and are indispensable in peptide chemistry, especially in machine-assisted SPPS. However, after the activating and coupling steps with these reagents in the presence of tertiary amines, Fmoc derivatives of...

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Détails bibliographiques
Publié dans:J Pept Sci
Auteurs principaux: Hibino, Hajime, Miki, Yasuyoshi, Nishiuchi, Yuji
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253322/
https://ncbi.nlm.nih.gov/pubmed/24357151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.2585
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