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Convenient Synthesis of Acetonide Protected 3,4-Dihydroxyphenylalanine (DOPA) for Fmoc Solid-Phase Peptide Synthesis

We report a facile approach to the synthesis of acetonide and Fmoc protected 3,4-dihydroxyphenylalanine (DOPA), Fmoc-DOPA(acetonide)-OH. By protecting the amino group of DOPA with a phthaloyl group and the carboxyl group as a methyl ester, acetonide protection of the catechol of DOPA derivative was...

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Auteurs principaux: Liu, Zhongqiang, Hu, Bi-huang, Messersmith, Phillip B.
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2598405/
https://ncbi.nlm.nih.gov/pubmed/19759805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2008.07.052
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