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Amicoumacin A inhibits translation by stabilizing mRNA interaction with the ribosome
We demonstrate that the antibiotic amicoumacin A (AMI) whose cellular target was unknown, is a potent inhibitor of protein synthesis. Resistance mutations in helix 24 of the 16S rRNA mapped the AMI binding site to the small ribosomal subunit. The crystal structure of bacterial ribosome in complex wi...
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| 發表在: | Mol Cell |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253140/ https://ncbi.nlm.nih.gov/pubmed/25306919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.020 |
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