Učitavanje...

Amicoumacin A inhibits translation by stabilizing mRNA interaction with the ribosome

We demonstrate that the antibiotic amicoumacin A (AMI) whose cellular target was unknown, is a potent inhibitor of protein synthesis. Resistance mutations in helix 24 of the 16S rRNA mapped the AMI binding site to the small ribosomal subunit. The crystal structure of bacterial ribosome in complex wi...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Mol Cell
Glavni autori: Polikanov, Yury S., Osterman, Ilya A., Szal, Teresa, Tashlitsky, Vadim N., Serebryakova, Marina V., Kusochek, Pavel, Bulkley, David, Malanicheva, Irina A., Efimenko, Tatyana A., Efremenkova, Olga V., Konevega, Andrey L., Shaw, Karen J., Bogdanov, Alexey A., Rodnina, Marina V., Dontsova, Olga A., Mankin, Alexander S., Steitz, Thomas A., Sergiev, Petr V.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253140/
https://ncbi.nlm.nih.gov/pubmed/25306919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.020
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!