Sorting Out Antibiotics' Mechanisms of Action: a Double Fluorescent Protein Reporter for High-Throughput Screening of Ribosome and DNA Biosynthesis Inhibitors

In order to accelerate drug discovery, a simple, reliable, and cost-effective system for high-throughput identification of a potential antibiotic mechanism of action is required. To facilitate such screening of new antibiotics, we created a double-reporter system for not only antimicrobial activity...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Osterman, Ilya A., Komarova, Ekaterina S., Shiryaev, Dmitry I., Korniltsev, Ilya A., Khven, Irina M., Lukyanov, Dmitry A., Tashlitsky, Vadim N., Serebryakova, Marina V., Efremenkova, Olga V., Ivanenkov, Yan A., Bogdanov, Alexey A., Sergiev, Petr V., Dontsova, Olga A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Analytical Procedures
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119032/
https://ncbi.nlm.nih.gov/pubmed/27736765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02117-16
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