Sorting Out Antibiotics' Mechanisms of Action: a Double Fluorescent Protein Reporter for High-Throughput Screening of Ribosome and DNA Biosynthesis Inhibitors

In order to accelerate drug discovery, a simple, reliable, and cost-effective system for high-throughput identification of a potential antibiotic mechanism of action is required. To facilitate such screening of new antibiotics, we created a double-reporter system for not only antimicrobial activity...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Osterman, Ilya A., Komarova, Ekaterina S., Shiryaev, Dmitry I., Korniltsev, Ilya A., Khven, Irina M., Lukyanov, Dmitry A., Tashlitsky, Vadim N., Serebryakova, Marina V., Efremenkova, Olga V., Ivanenkov, Yan A., Bogdanov, Alexey A., Sergiev, Petr V., Dontsova, Olga A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Analytical Procedures
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119032/
https://ncbi.nlm.nih.gov/pubmed/27736765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02117-16
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