Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity

Cereblon, a member of the cullin 4 ring ligase complex (CRL4), is the molecular target of the immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide and is required for the antiproliferative activity of these agents in multiple myeloma (MM) and immunomodulatory activity in T cells. Cereblon�...

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Detalles Bibliográficos
Publicado en:Br J Haematol
Main Authors: Gandhi, Anita K, Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E, Schafer, Peter H, Daniel, Tom O, Lopez-Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
Assuntos:
Haematological Malignancy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253085/
https://ncbi.nlm.nih.gov/pubmed/24206017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12622
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