Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity

Cereblon, a member of the cullin 4 ring ligase complex (CRL4), is the molecular target of the immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide and is required for the antiproliferative activity of these agents in multiple myeloma (MM) and immunomodulatory activity in T cells. Cereblon�...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Gandhi, Anita K, Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E, Schafer, Peter H, Daniel, Tom O, Lopez-Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Haematological Malignancy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253085/
https://ncbi.nlm.nih.gov/pubmed/24206017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12622
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