Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma

Emergence of drug resistance to all available therapies is the major challenge to improving survival in myeloma. Cereblon (CRBN) is the essential binding protein of the widely used immunomodulatory drugs (IMiDs) and novel CRBN E3 ligase modulator drugs (CELMoDs) in myeloma, as well as certain proteo...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Gooding, Sarah, Ansari-Pour, Naser, Towfic, Fadi, Ortiz Estévez, María, Chamberlain, Philip P., Tsai, Kao-Tai, Flynt, Erin, Hirst, Marissa, Rozelle, Dan, Dhiman, Paula, Neri, Paola, Ramasamy, Karthik, Bahlis, Nizar, Vyas, Paresh, Thakurta, Anjan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893409/
https://ncbi.nlm.nih.gov/pubmed/33443552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007081
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