An Investigation of the Molecular Mechanisms Engaged Prior and Subsequent to the Development of Alzheimer Disease Neuropathology in Down Syndrome: A Proteomics Approach

Down syndrome (DS) is one of the most common causes of intellectual disability, due to trisomy of all or part of chromosome 21. DS is also associated with the development of Alzheimer disease (AD) neuropathology after the age of 40 years. To better clarify the cellular and metabolic pathways that co...

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Pubblicato in:Free Radic Biol Med
Autori principali: Cenini, Giovanna, Fiorini, Ada, Sultana, Rukhsana, Perluigi, Marzia, Cai, Jian, Klein, Jon B., Head, Elizabeth, Butterfield, D. Allan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252833/
https://ncbi.nlm.nih.gov/pubmed/25151119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.08.006
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