Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer’s disease neuropathology: Redox proteomics analysis of human brain

DS is the most frequent genetic cause of intellectual disability characterized by the anomalous presence of three copies of chromosome 21. One of the peculiar features of DS is the onset of Alzheimer’s disease neuropathology after the age of 40 years characterized by deposition of senile plaques and...

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Détails bibliographiques
Auteurs principaux: Di Domenico, Fabio, Coccia, Raffaella, Cocciolo, Annalisa, Murphy, M. Paul, Cenini, Giovanna, Head, Elizabeth, Butterfield, D. Allan, Giorgi, Alessandra, Schinina, Maria Eugenia, Mancuso, Cesare, Cini, Chiara, Perluigi, Marzia
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940071/
https://ncbi.nlm.nih.gov/pubmed/23603808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2013.04.013
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