Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer’s disease neuropathology: Redox proteomics analysis of human brain

DS is the most frequent genetic cause of intellectual disability characterized by the anomalous presence of three copies of chromosome 21. One of the peculiar features of DS is the onset of Alzheimer’s disease neuropathology after the age of 40 years characterized by deposition of senile plaques and...

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Main Authors: Di Domenico, Fabio, Coccia, Raffaella, Cocciolo, Annalisa, Murphy, M. Paul, Cenini, Giovanna, Head, Elizabeth, Butterfield, D. Allan, Giorgi, Alessandra, Schinina, Maria Eugenia, Mancuso, Cesare, Cini, Chiara, Perluigi, Marzia
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940071/
https://ncbi.nlm.nih.gov/pubmed/23603808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2013.04.013
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