Tau-Mediated NMDA Receptor Impairment Underlies Dysfunction of a Selectively Vulnerable Network in a Mouse Model of Frontotemporal Dementia

Frontotemporal dementia (FTD) is a neurodegenerative behavioral disorder that selectively affects the salience network, including the ventral striatum and insula. Tau mutations cause FTD, but how mutant tau impairs the salience network is unknown. Here, we address this question using a mouse model e...

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Publicado en:J Neurosci
Main Authors: Warmus, Brian A., Sekar, Dheepa R., McCutchen, Eve, Schellenberg, Gerard D., Roberts, Rosalinda C., McMahon, Lori L., Roberson, Erik D.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252555/
https://ncbi.nlm.nih.gov/pubmed/25471585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3418-14.2014
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