Tau-Mediated NMDA Receptor Impairment Underlies Dysfunction of a Selectively Vulnerable Network in a Mouse Model of Frontotemporal Dementia

Frontotemporal dementia (FTD) is a neurodegenerative behavioral disorder that selectively affects the salience network, including the ventral striatum and insula. Tau mutations cause FTD, but how mutant tau impairs the salience network is unknown. Here, we address this question using a mouse model e...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Warmus, Brian A., Sekar, Dheepa R., McCutchen, Eve, Schellenberg, Gerard D., Roberts, Rosalinda C., McMahon, Lori L., Roberson, Erik D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252555/
https://ncbi.nlm.nih.gov/pubmed/25471585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3418-14.2014
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