Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure

Nef plays a major role in HIV-1 pathogenicity. We studied HIV-1 subtype C infected individuals in acute/early (n=120) or chronic (n=207) infection to investigate the relationship between Nef-mediated CD4/HLA-I down-regulation activities and disease progression, and the influence of immune-driven seq...

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Publicado en:Virology
Main Authors: Mann, Jaclyn K., Chopera, Denis, Omarjee, Saleha, Kuang, Xiaomei T., Le, Anh Q., Anmole, Gursev, Danroth, Ryan, Mwimanzi, Philip, Reddy, Tarylee, Carlson, Jonathan, Radebe, Mopo, Goulder, Philip J.R., Walker, Bruce D., Karim, Salim Abdool, Novitsky, Vladimir, Williamson, Carolyn, Brockman, Mark A., Brumme, Zabrina L., Ndung’u, Thumbi
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252354/
https://ncbi.nlm.nih.gov/pubmed/25193656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.08.009
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