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Improving clinical efficacy of adeno associated vectors by rational capsid bioengineering
Adeno associated vectors (AAV) have shown considerable promise to treat various genetic disorders in both preclinical and clinical settings mainly because of its safety profile. However, efficient use of AAV to deliver genes in immune-competent sites like muscles and liver requires very high doses w...
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| Publicado no: | J Biomed Sci |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4251935/ https://ncbi.nlm.nih.gov/pubmed/25425174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-014-0103-1 |
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