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A catalytic asymmetric total synthesis of (–)-perophoramidine

We report a catalytic asymmetric total synthesis of the ascidian natural product perophoramidine. The synthesis employs a molybdenum-catalyzed asymmetric allylic alkylation of an oxindole nucleophile and a monosubstituted allylic electrophile as a key asymmetric step. The enantioenriched oxindole pr...

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Publicado en:Chem Sci
Autores principales: Trost, B. M., Osipov, M., Krüger, S., Zhang, Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251524/
https://ncbi.nlm.nih.gov/pubmed/25485074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc01826e
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