Hepatocyte Growth Factor Ameliorates Hyperglycemia and Corrects β-Cell Mass in IRS2-Deficient Mice

Insulin resistance, when combined with decreased β-cell mass and relative insufficient insulin secretion, leads to type 2 diabetes. Mice lacking the IRS2 gene (IRS2(−/−) mice) develop diabetes due to uncompensated insulin resistance and β-cell failure. Hepatocyte growth factor (HGF) activates the ph...

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Bibliografski detalji
Izdano u:Mol Endocrinol
Glavni autori: Alvarez-Perez, Juan C., Rosa, Taylor C., Casinelli, Gabriella P., Valle, Shelley R., Lakshmipathi, Jayalakshmi, Rosselot, Carolina, Rausell-Palamos, Francisco, Vasavada, Rupangi C., García-Ocaña, Adolfo
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2014
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250367/
https://ncbi.nlm.nih.gov/pubmed/25361392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1207
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