Novel Proapoptotic Effect of Hepatocyte Growth Factor: Synergy with Palmitate to Cause Pancreatic β-Cell Apoptosis

Increasing evidence suggests that elevation of plasma fatty acids that often accompanies insulin resistance contributes to β-cell insufficiency in obesity-related type 2 diabetes. Circulating levels of hepatocyte growth factor (HGF) are increased in humans with metabolic syndrome and obesity. HGF is...

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Main Authors: González-Pertusa, José A., Dubé, John, Valle, Shelley R., Rosa, Taylor C., Takane, Karen K., Mellado-Gil, José M., Perdomo, Germán, Vasavada, Rupangi C., García-Ocaña, Adolfo
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850223/
https://ncbi.nlm.nih.gov/pubmed/20176723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0975
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