Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity, and Ameliorates Type 1 Diabetes

A failure in self-tolerance leads to autoimmune destruction of pancreatic β-cells and type 1 diabetes (T1D). Low-molecular-weight dextran sulfate (DS) is a sulfated semisynthetic polysaccharide with demonstrated cytoprotective and immunomodulatory properties in vitro. However, whether DS can protect...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Diabetes
Prif Awduron: Lu, Geming, Rausell-Palamos, Francisco, Zhang, Jiamin, Zheng, Zihan, Zhang, Tuo, Valle, Shelley, Rosselot, Carolina, Berrouet, Cecilia, Conde, Patricia, Spindler, Matthew P., Graham, John G., Homann, Dirk, Garcia-Ocaña, Adolfo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Diabetes Association 2020
Pynciau:
Islet Studies
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372066/
https://ncbi.nlm.nih.gov/pubmed/32381645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0725
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