PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

Malignant Peripheral Nerve Sheath Tumors (MPNSTs) represent a group of highly aggressive soft tissue sarcomas that may occur sporadically, in association with neurofibromatosis type I (NF1-), or after radiotherapy(1–3). Using comprehensive genomic approaches, we identified loss-of-function (LOF) som...

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Publicat a:Nat Genet
Autors principals: Lee, William, Teckie, Sewit, Wiesner, Thomas, Ran, Leili, Prieto Granada, Carlos N., Lin, Mingyan, Zhu, Sinan, Cao, Zhen, Liang, Yupu, Sboner, Andrea, Tap, William D., Fletcher, Jonathan A., Huberman, Kety H., Qin, Li-Xuan, Viale, Agnes, Singer, Samuel, Zheng, Deyou, Berger, Michael F., Chen, Yu, Antonescu, Cristina R., Chi, Ping
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249650/
https://ncbi.nlm.nih.gov/pubmed/25240281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3095
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