Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis

BACKGROUND: Tumor cells exhibit abnormal actin remodeling profiles, which involve the altered expressions of several important actin-binding proteins. Profilin1 (Pfn1), originally identified as an actin-associated protein, has been linked to several human malignancies. Our recent studies suggested t...

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Veröffentlicht in:Mol Cancer
Hauptverfasser: Yao, Wantong, Ji, Shunrong, Qin, Yi, Yang, Jingxuan, Xu, Jin, Zhang, Bo, Xu, Wenyan, Liu, Jiang, Shi, Si, Liu, Liang, Liu, Chen, Long, Jiang, Ni, Quanxing, Li, Min, Yu, Xianjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249601/
https://ncbi.nlm.nih.gov/pubmed/25103363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-187
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