Heterogeneity of mprF Sequences in Methicillin-Resistant Staphylococcus aureus Clinical Isolates: Role in Cross-Resistance between Daptomycin and Host Defense Antimicrobial Peptides

Over the past several years, single-nucleotide polymorphisms (SNPs) within the mprF open reading frame (ORF) have been proposed to be associated with a gain-of-function phenotype in terms of daptomycin (DAP) nonsusceptibility (referred to as daptomycin resistance [DAP-R] herein for ease of presentat...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Bayer, Arnold S., Mishra, Nagendra N., Sakoulas, George, Nonejuie, Poochit, Nast, Cynthia C., Pogliano, Joseph, Chen, Kuan-Tsen, Ellison, Steven N., Yeaman, Michael R., Yang, Soo-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249560/
https://ncbi.nlm.nih.gov/pubmed/25288091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03422-14
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