Emergence of Daptomycin Resistance in Daptomycin-Naïve Rabbits with Methicillin-Resistant Staphylococcus aureus Prosthetic Joint Infection Is Associated with Resistance to Host Defense Cationic Peptides and mprF Polymorphisms

BACKGROUND: Previous studies of both clinically-derived and in vitro passage-derived daptomycin–resistant (DAP-R) Staphylococcus aureus strains demonstrated the coincident emergence of increased DAP MICs and resistance to host defense cationic peptides (HDP-R). METHODS: In the present investigation,...

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Detalhes bibliográficos
Main Authors: Mishra, Nagendra N., Yang, Soo-Jin, Chen, Liang, Muller, Claudette, Saleh-Mghir, Azzam, Kuhn, Sebastian, Peschel, Andreas, Yeaman, Michael R., Nast, Cynthia C., Kreiswirth, Barry N., Crémieux, Anne-Claude, Bayer, Arnold S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747195/
https://ncbi.nlm.nih.gov/pubmed/23990934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071151
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