Giardial Triosephosphate Isomerase as Possible Target of the Cytotoxic Effect of Omeprazole in Giardia lamblia

Giardiasis is highly prevalent in the developing world, and treatment failures with the standard drugs are common. This work deals with the proposal of omeprazole as a novel antigiardial drug, focusing on a giardial glycolytic enzyme used to follow the cytotoxic effect at the molecular level. We use...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Reyes-Vivas, Horacio, de la Mora-de la Mora, Ignacio, Castillo-Villanueva, Adriana, Yépez-Mulia, Lilian, Hernández-Alcántara, Gloria, Figueroa-Salazar, Rosalia, García-Torres, Itzhel, Gómez-Manzo, Saúl, Méndez, Sara T., Vanoye-Carlo, América, Marcial-Quino, Jaime, Torres-Arroyo, Angélica, Oria-Hernández, Jesús, Gutiérrez-Castrellón, Pedro, Enríquez-Flores, Sergio, López-Velázquez, Gabriel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249547/
https://ncbi.nlm.nih.gov/pubmed/25223993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02900-14
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