Giardial Triosephosphate Isomerase as Possible Target of the Cytotoxic Effect of Omeprazole in Giardia lamblia

Giardiasis is highly prevalent in the developing world, and treatment failures with the standard drugs are common. This work deals with the proposal of omeprazole as a novel antigiardial drug, focusing on a giardial glycolytic enzyme used to follow the cytotoxic effect at the molecular level. We use...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Reyes-Vivas, Horacio, de la Mora-de la Mora, Ignacio, Castillo-Villanueva, Adriana, Yépez-Mulia, Lilian, Hernández-Alcántara, Gloria, Figueroa-Salazar, Rosalia, García-Torres, Itzhel, Gómez-Manzo, Saúl, Méndez, Sara T., Vanoye-Carlo, América, Marcial-Quino, Jaime, Torres-Arroyo, Angélica, Oria-Hernández, Jesús, Gutiérrez-Castrellón, Pedro, Enríquez-Flores, Sergio, López-Velázquez, Gabriel
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249547/
https://ncbi.nlm.nih.gov/pubmed/25223993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02900-14
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