Structural and Functional Perturbation of Giardia lamblia Triosephosphate Isomerase by Modification of a Non-Catalytic, Non-Conserved Region

BACKGROUND: We have previously proposed triosephosphate isomerase of Giardia lamblia (GlTIM) as a target for rational drug design against giardiasis, one of the most common parasitic infections in humans. Since the enzyme exists in the parasite and the host, selective inhibition is a major challenge...

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Hlavní autoři: Hernández-Alcántara, Gloria, Torres-Larios, Alfredo, Enríquez-Flores, Sergio, García-Torres, Itzhel, Castillo-Villanueva, Adriana, Méndez, Sara T., de la Mora-de la Mora, Ignacio, Gómez-Manzo, Saúl, Torres-Arroyo, Angélica, López-Velázquez, Gabriel, Reyes-Vivas, Horacio, Oria-Hernández, Jesús
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718800/
https://ncbi.nlm.nih.gov/pubmed/23894402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069031
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