Switching from Posaconazole Suspension to Tablets Increases Serum Drug Levels in Leukemia Patients without Clinically Relevant Hepatotoxicity

We evaluated posaconazole serum concentrations and hepatotoxicity in 12 leukemia patients who transitioned from posaconazole suspension to tablets. Patients who switched to tablets had significantly increased posaconazole concentrations (median: suspension, 748 ng/ml; tablet, 1,910 ng/ml; P < 0.0...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Jung, Dong Sik, Tverdek, Frank P., Kontoyiannis, Dimitrios P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Clinical Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249440/
https://ncbi.nlm.nih.gov/pubmed/25199774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04035-14
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